Author

R. Cortes

Spanish National Centre for Cardiovascular Research

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Molecular Biology· 1

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Approach:experimental assay· 1 Organism:human· 1

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Andrea CurtabbiiD· 1 shared José Antonio Enrı́queziD· 1 shared

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2024-2024 · peak 1/yr

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1 shared paperMolecular Biology

Andrea CurtabbiORCID

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Recent·Most cited

Uncoupling de novo pyrimidine biosynthesis from mitochondrial electron transport by ectopic expression of cytosolic DHODH

Andrea Curtabbi, R. Cortes, José Antonio Enrı́quez

This paper shows that expressing ScURA in mammalian cells allows pyrimidine biosynthesis independent of mitochondrial electron transport, enabling growth in uridine-deficient medium and improving mitochondrial disease models.

bioRxiv · Aug 9, 2024 · PreprintMolecular Biology