Across kingdom biased CYP-mediated metabolism via small-molecule ligands docking on P450 oxidoreductase
S. B. Jensen, S. Thodberg, S. Parween, M. E. Moses, C. C. Hansen, J. Thomsen, M. B. Sletfjerding, C. Knudsen, R. D. Giudice, P. M. Lund, P. R. Castano, Y. G. Bustamante, F. S. Jorgensen, A. V. Pandey, T. Laursen, , N. S. Hatzakis
The paper identifies ligands that dock on P450 oxidoreductase (POR) to bias its specificity towards CYP redox partners, revealing a mechanism for pathway-specific metabolism.
bioRxiv · Sep 23, 2020 · PreprintBiophysics