S. Parween

Mangrove endophytes shorten the life cycle of rice while enhancing yield and salt tolerance

This study shows that mangrove endophytes enhance rice yield and salt tolerance while shortening its life cycle.

Skin Sensitisation Case Study: Comparison of Defined Approaches including OECD 497 Guidance

The paper compares different defined approaches for skin sensitisation assessment, including OECD guidance and emerging methods, to evaluate their effectiveness in characterising chemical compounds.

Across kingdom biased CYP-mediated metabolism via small-molecule ligands docking on P450 oxidoreductase

The paper identifies ligands that dock on P450 oxidoreductase (POR) to bias its specificity towards CYP redox partners, revealing a mechanism for pathway-specific metabolism.

Differential effects of variations in human P450 oxidoreductase on the aromatase activity of CYP19A1 polymorphisms R264C and R264H

This study investigates how variations in P450 oxidoreductase (POR) affect the aromatase activity of CYP19A1 polymorphisms R264C and R264H, showing differential impacts based on POR variants.

Bioactivity of curcumin on the cytochrome P450 enzymes of the steroidogenic pathways

This study investigates the effects of curcuminoids on cytochrome P450 enzymes involved in steroid metabolism, finding significant inhibition of CYP17A1 and CYP19A1 activities.

Loss of multiple enzyme activities due to the human genetic variation P284T in NADPH cytochrome P450 oxidoreductase

This study investigates the impact of the P284T variant in POR on cytochrome P450 enzyme activities, finding significant reductions in several key functions.

Variability in Human Drug Metabolizing Cytochrome P450 CYP2C9, CYP2C19 and CYP3A5 Activities Caused by Genetic Variations in Cytochrome P450 Oxidoreductase

This study identifies POR variants affecting CYP2C9, CYP2C19, and CYP3A5 activities and shows their impact on drug metabolism.