Author

R. D. Kortschak

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Biology Disciplines

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Evolutionary Biology· 3 Pharmacology & Toxicology· 3

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:chromatin & epigenetic regulation· 3 Approach:comparative / phylogenetic analysis· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

D. L. Adelson· 6 shared J. Cui· 3 shared W. Wang· 3 shared Y. Harata-Lee· 3 shared Z. Qu· 3 shared H. Shen· 2 shared R. M. Buckley· 2 shared T. Nwe Aung· 2 shared

Activity by Year

2017-2021 · peak 2/yr

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10 top collaborators · 29 mutual co-author links

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6 shared papersEvolutionary Biology

D. L. Adelson

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6 papers

Recent·Most cited

Genome stability is in the eye of the beholder: recent retrotransposon activity varies significantly across avian diversity

J. D. Galbraith, R. D. Kortschak, A. Suh, D. L. Adelson

This study examines CR1 retrotransposon activity across avian species, finding significant variation in TE expansion rates among orders and clades, challenging the notion of low TE activity in birds.

bioRxiv · Apr 13, 2021Evolutionary Biology

Understanding the Mechanistic Contribution of Herbal Extracts in Compound Kushen Injection with Transcriptome Analysis

H. Shen, Z. Qu, Y. Harata-Lee, T. Nwe Aung, J. Cui, W. Wang, R. D. Kortschak, D. L. Adelson

This study uses transcriptome analysis to investigate how two herbal extracts in Compound Kushen Injection interact, showing Kushen drives cytotoxicity and Baituling enhances it while activating immune pathways.

bioRxiv · Mar 31, 2019Pharmacology & Toxicology

A new strategy for identifying mechanisms of drug-drug interaction using transcriptome analysis: Compound Kushen injection as a proof of principle

H. Y. Shen, Z. Qu, Y. Harata-Lee, J. Cui, T. Nwe Aung, W. Wang, R. D. Kortschak, D. L. Adelson

This paper introduces a transcriptome analysis workflow to study drug-drug interactions, using Compound Kushen Injection and chemotherapy drugs as a proof of principle, identifying MYD88 as a key regulator.

bioRxiv · Mar 30, 2019Pharmacology & Toxicology

The Effect of Compound Kushen Injection on Cancer Cells: Integrated Identification of Candidate Molecular Mechanisms.

J. Cui, Z. Qu, Y. Harata-Lee, H. Shen, T. N. Aung, W. Wang, R. D. Kortschak, D. L. Adelson

This study identifies candidate molecular mechanisms of Compound Kushen Injection by analyzing transcriptome changes in cancer cells and linking them to gene expression and pathway alterations.

bioRxiv · Dec 21, 2018Pharmacology & Toxicology

Divergent genome evolution caused by regional variation in DNA gain and loss between human and mouse

R. M. Buckley, R. D. Kortschak, D. L. Adelson

This study identifies regional variation in DNA gain and loss between human and mouse genomes, linking these events to chromatin states and biological processes.

bioRxiv · Aug 21, 2017Evolutionary Biology

Similar evolutionary trajectories for retrotransposon accumulation in mammals

R. M. Buckley, R. D. Kortschak, J. M. Raison, D. L. Adelson

The paper investigates retrotransposon accumulation patterns across mammalian genomes, finding similar evolutionary trajectories despite differences in retrotransposon types.

bioRxiv · May 16, 2017Evolutionary Biology