Author

Y. Harata-Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 4 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 6 Assay:bulk RNA-seq· 5 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

D. L. Adelson· 6 shared J. Cui· 6 shared Z. Qu· 6 shared H. Shen· 4 shared T. N. Aung· 4 shared W. Wang· 4 shared R. D. Kortschak· 3 shared A. J. Yool· 2 shared

Activity by Year

2018-2019 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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6 shared papersPharmacology & Toxicology

D. L. Adelson

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6 papers

Recent·Most cited

Understanding the Mechanistic Contribution of Herbal Extracts in Compound Kushen Injection with Transcriptome Analysis

H. Shen, Z. Qu, Y. Harata-Lee, T. Nwe Aung, J. Cui, W. Wang, R. D. Kortschak, D. L. Adelson

This study uses transcriptome analysis to investigate how two herbal extracts in Compound Kushen Injection interact, showing Kushen drives cytotoxicity and Baituling enhances it while activating immune pathways.

bioRxiv · Mar 31, 2019Pharmacology & Toxicology

A new strategy for identifying mechanisms of drug-drug interaction using transcriptome analysis: Compound Kushen injection as a proof of principle

H. Y. Shen, Z. Qu, Y. Harata-Lee, J. Cui, T. Nwe Aung, W. Wang, R. D. Kortschak, D. L. Adelson

This paper introduces a transcriptome analysis workflow to study drug-drug interactions, using Compound Kushen Injection and chemotherapy drugs as a proof of principle, identifying MYD88 as a key regulator.

bioRxiv · Mar 30, 2019Pharmacology & Toxicology

The Effect of Compound Kushen Injection on Cancer Cells: Integrated Identification of Candidate Molecular Mechanisms.

J. Cui, Z. Qu, Y. Harata-Lee, H. Shen, T. N. Aung, W. Wang, R. D. Kortschak, D. L. Adelson

This study identifies candidate molecular mechanisms of Compound Kushen Injection by analyzing transcriptome changes in cancer cells and linking them to gene expression and pathway alterations.

bioRxiv · Dec 21, 2018Pharmacology & Toxicology

Effect of Compound Kushen Injection, a natural compound mixture, and its identified chemical components on migration and invasion of colon, brain and breast cancer cell lines

S. Nourmohammadi, T. N. Aung, J. Cui, J. V. Pei, M. L. De Ieso, Y. Harata-Lee, Z. Qu, D. L. Adelson, A. J. Yool

This study evaluates the effects of Compound Kushen Injection and its components on cancer cell migration and invasion in multiple cell lines, finding reduced motility and invasiveness.

bioRxiv · Dec 19, 2018Cancer Biology

Fractional Deletion Of Compound Kushen Injection, A Natural Compound Mixture, Indicates Cytokine Signaling Pathways Are Critical For Its Perturbation Of The Cell Cycle.

T. N. Aung, S. Nourmohammadi, Z. Qu, Y. Harata-Lee, J. Cui, H. Shen, A. J. Yool, T. Pukala, H. Du, D. Kortschak, D. L. Adelson

This study identifies critical compounds in Compound Kushen Injection (CKI) that modulate cell cycle and apoptosis through cytokine signaling pathways.

bioRxiv · Dec 9, 2018Pharmacology & Toxicology

Cell Cycle, Energy Metabolism and DNA Repair Pathways in Cancer Cells are Suppressed by Compound Kushen Injection.

J. Cui, Z. Qu, Y. Harata-Lee, T. N. Aung, H. Shen, W. Wang, D. L. Adelson

This study shows that Compound Kushen Injection suppresses cell cycle, DNA repair, and energy metabolism in cancer cells, while its major component oxymatrine has limited effects.

bioRxiv · Jun 21, 2018Cancer Biology