Z. Qu

AMHY and sex determination in egg-laying mammals

This study identifies AMHY as the primary male sex determination gene in monotremes by analyzing its expression and function during sexual differentiation.

Validating the Target Functions and Synergistic Multi-Target, Multi-Pathway Action Mode of Compound Kushen Injection Using CRISPR/CAS

This study validates the multi-target, multi-pathway action of Compound Kushen Injection by knocking out key genes in cell lines and observing changes in CKI efficacy.

Pseudogenisation of NK3 Homeobox 2 (Nkx3.2) in Monotremes Provides Insight into Unique Gastric Anatomy and Physiology

The paper identifies pseudogenisation of Nkx3.2 in monotremes and links it to unique gastric anatomy and physiology, suggesting gene loss influences phenotypic evolution.

Loss of Tip60-dependent H2A.Z acetylation reprogramscardiomyocyte identity toward a regenerative state.

This study shows that Tip60-dependent H2A.Z acetylation maintains cardiomyocyte differentiation, and its loss reprograms CMs toward a regenerative state by inducing dedifferentiation and metabolic shifts.

Siderophore synthetase-receptor gene coevolution reveals habitat- and pathogen-specific bacterial iron interaction networks

The paper develops a co-evolution algorithm to predict bacterial iron interaction networks based on siderophore synthetase-receptor gene pairs across Pseudomonas genomes, revealing habitat- and pathogen-specific interactions.

Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2

This study develops nanoPDLIM2, a PDLIM2-expressing nanoparticle, which enhances PD-1 blockade and chemotherapy efficacy in lung cancer by reactivating tumor immunity and reducing drug resistance.

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

This study shows that a PTP1B/PTPN2 inhibitor enhances T cell anti-tumor immunity in mice, improves tumor response to PD1 therapy, and avoids immune-related toxicities.

Novel populations of Tr1 cells contribute to the resolution of acute influenza A virus infection.

The paper identifies novel Tr1 cell populations in the lungs of mice during recovery from acute influenza A virus infection, showing their suppressive role and distinct functional dependencies.

Machine Learning Workflow for Single-Cell Antimicrobial Susceptibility Testing of Klebsiella pneumoniae to Meropenem in Sub-Doubling Time

This paper develops a machine learning workflow to predict antimicrobial susceptibility and MIC of Klebsiella pneumoniae to meropenem using single-cell morphological features within sub-doubling time.

Bistable nerve conduction

This paper demonstrates that nerve systems can exhibit bistable conduction, where stimulus-dependent fast and slow conduction waves occur due to sodium channel inactivation and calcium current interactions.

Myofibroblast Senescence Promotes Arrhythmogenic Remodeling in the Aged Infarcted Rabbit Heart

This study shows that myofibroblast senescence in aged infarcted rabbit hearts promotes arrhythmogenic remodeling by coupling with myocytes and prolonging action potential duration.

A vimentin-targeting oral compound with host-directed antiviral and anti-inflammatory actions addresses multiple features of COVID-19 and related diseases

This paper reports the preclinical efficacy of ALD-R491, a vimentin-targeting compound, in treating COVID-19 by reducing viral entry, enhancing pathogen clearance, and suppressing overreactive immune responses.

Spatial profiling of microbial communities by sequential FISH with error-robust encoding

This paper introduces SEER-FISH, a method for spatially profiling microbial communities with high multiplexity and accuracy, demonstrating its ability to quantify taxon abundance and map microbial biogeography.

A meta-analysis on uncertainty monitoring in four non-primate animal species: Pigeons, rats, large-billed crows, and bees

This study conducts a meta-analysis of uncertainty monitoring in four non-primate species, finding significant positive effect sizes and identifying contributing moderators.

Delayed global feedback in the genesis and stability of spatiotemporal patterns in paced biological excitable media

The paper investigates how delayed global feedback influences the formation and stability of spatiotemporal patterns in excitable media using simulations and theoretical analysis.

Horseshoe crab genomes reveal the evolutionary fates of genes and microRNAs after three rounds (3R) of whole genome duplication

MicroRNA clusters integrate evolutionary constraints on expression and target affinities: the miR-6/5/4/286/3/309 cluster in Drosophila leg development

The paper investigates a microRNA cluster in Drosophila leg development, showing that clustering integrates evolutionary constraints on expression and target affinities.

A common problem in the purification of calicivirus raised by molecular sieving: balance between purification and loss of viral particles

This study evaluates the impact of molecular sieving on Feline Calicivirus stability using cryo-EM and develops a scoring system to assess purification effects.

Millipede genomes reveal unique adaptation of genes and microRNAs during myriapod evolution

This paper sequenced two millipede genomes, revealing unique genomic features, defense systems, and microRNA regulation mechanisms in myriapods.

Quantification of human-mosquito contact rate using surveys and its application in determining dengue viral transmission risk

This study estimates human-mosquito contact rates using surveys and applies a mathematical model to assess dengue transmission risk in two locations in the Greater New Orleans Region.

Controlling Organization and Forces in Active Matter Through Optically-Defined Boundaries

This paper demonstrates the use of optically-defined boundaries to control active matter systems of microtubules and motor proteins, enabling the creation of contractile networks and fluid flows.

A spatiotemporal ventricular myocyte model incorporating mitochondrial calcium cycling

This paper develops a spatiotemporal ventricular myocyte model that integrates mitochondrial Ca2+ cycling and ROS signaling to study their effects on intracellular Ca2+ dynamics and action potential behavior.

Understanding the Mechanistic Contribution of Herbal Extracts in Compound Kushen Injection with Transcriptome Analysis

This study uses transcriptome analysis to investigate how two herbal extracts in Compound Kushen Injection interact, showing Kushen drives cytotoxicity and Baituling enhances it while activating immune pathways.

A new strategy for identifying mechanisms of drug-drug interaction using transcriptome analysis: Compound Kushen injection as a proof of principle

This paper introduces a transcriptome analysis workflow to study drug-drug interactions, using Compound Kushen Injection and chemotherapy drugs as a proof of principle, identifying MYD88 as a key regulator.

Anti-biofilm Activity of Graphene Quantum Dots via Self-Assembly with Bacterial Amyloid Proteins

This paper shows graphene quantum dots disrupt Staphylococcus aureus biofilms by binding to amyloid fibers and preventing their fibrillation.

Compartmentalized Biosynthesis of Mycophenolic Acid

This paper elucidates the compartmentalized biosynthetic pathway of mycophenolic acid, revealing subcellular localization of enzymes and cooperation with β-oxidation machinery.

The Effect of Compound Kushen Injection on Cancer Cells: Integrated Identification of Candidate Molecular Mechanisms.

This study identifies candidate molecular mechanisms of Compound Kushen Injection by analyzing transcriptome changes in cancer cells and linking them to gene expression and pathway alterations.

Effect of Compound Kushen Injection, a natural compound mixture, and its identified chemical components on migration and invasion of colon, brain and breast cancer cell lines

This study evaluates the effects of Compound Kushen Injection and its components on cancer cell migration and invasion in multiple cell lines, finding reduced motility and invasiveness.

Fractional Deletion Of Compound Kushen Injection, A Natural Compound Mixture, Indicates Cytokine Signaling Pathways Are Critical For Its Perturbation Of The Cell Cycle.

This study identifies critical compounds in Compound Kushen Injection (CKI) that modulate cell cycle and apoptosis through cytokine signaling pathways.

Determinants of early afterdepolarization properties in ventricular myocyte models

This study investigates EAD properties in ventricular myocyte models, finding discrepancies between model predictions and experimental observations, particularly in inter-EAD intervals.