Author

R. E. Kleiner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Research Focus:cell type annotation· 5 Assay:bulk RNA-seq· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. E. Arguello· 3 shared A. Li· 3 shared D. Wang· 2 shared N. J. Yu· 2 shared A. N. DeLiberto· 1 shared A. Shalamberidze· 1 shared B. Purse· 1 shared E. McCann Smith· 1 shared

Activity by Year

2022-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiochemistry

A. E. Arguello

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Author profile →

7 papers

Recent·Most cited

Chemoproteomic profiling of 8-oxoguanosine-sensitive RNA-protein interactions

J. Villers, E. McCann Smith, A. N. DeLiberto, A. E. Arguello, J. Nyaanga, R. E. Kleiner

The paper investigates how 8-oxoguanosine (8OG) affects RNA-protein interactions by identifying proteins that bind or are repelled by 8OG-modified RNA.

Biochemistry · Nov 27, 2023Peer-reviewedBiochemistry

A minimal sequence motif drives selective tRNA dihydrouridylation by hDUS2

J. Ji, N. J. Yu, R. E. Kleiner

This study identifies a minimal GU motif that directs hDUS2 to modify U20 in tRNA and develops a platform to screen inhibitors of hDUS2.

bioRxiv · Nov 4, 2023 · PreprintBiochemistry

Cell type-specific translational regulation by human DUS enzymes

N. J. Yu, W. Dai, A. Li, M. He, R. E. Kleiner

This study identifies DUS enzymes' role in tRNA modification and shows cell type-specific effects on translation.

bioRxiv · Nov 3, 2023 · PreprintBiochemistry

Transcriptome-wide RNA structure probing with temporal resolution

D. Wang, Y. Tang, A. Li, L. Sun, R. E. Kleiner

This paper introduces SNIPER-seq, a method to map RNA structure dynamics with temporal resolution, revealing structural changes in human 5S rRNA during ribosome biogenesis.

bioRxiv · Sep 28, 2023 · PreprintBiochemistry

Profiling dynamic RNA-protein interactions using small molecule-induced RNA editing

K. W. Seo, R. E. Kleiner

This study introduces TRIBE-ID, a method to profile RNA-protein interactions with temporal control, showing stress granules enhance G3BP1-RNA interactions and stabilize RNA clients.

bioRxiv · Jun 30, 2022Biochemistry

Live-cell RNA imaging with metabolically incorporated fluorescent nucleosides

D. Wang, A. Shalamberidze, A. E. Arguello, B. Purse, R. E. Kleiner

This paper develops a method for live-cell RNA imaging using fluorescent nucleosides and shows accelerated RNA turnover and distinct RNA granules during oxidative stress.

bioRxiv · Mar 22, 2022Biochemistry

A chemical method to sequence 5-formylcytosine on RNA

A. Li, X. Sun, A. E. Arguello, R. E. Kleiner

The paper introduces Mal-Seq, a chemical method to sequence 5-formylcytosine (f5C) on RNA, and shows its presence in mammalian mitochondrial tRNA but not in lower eukaryotes.

ACS Chemical Biology · Feb 25, 2022Peer-reviewedBiochemistry