Author

R. E. Marioni

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

E. Latorre-Crespo· 2 shared T. Chandra· 2 shared A. C. Purcell· 1 shared A. Fawkes· 1 shared B. J. Livesey· 1 shared D. J. Simpson· 1 shared D. L. Mccartney· 1 shared E. J. Yang· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

E. Latorre-Crespo

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2 papers

Recent·Most cited

Probabilistic inference of epigenetic age acceleration from cellular dynamics

J. K. Dabrowski, E. J. Yang, S. J. C. Crofts, R. F. Hillary, D. J. Simpson, D. L. Mccartney, R. E. Marioni, E. Latorre-Crespo, T. Chandra

The paper develops a probabilistic model to infer epigenetic age acceleration from cellular dynamics, identifying acceleration and bias as measurable components linked to physiological traits and genomic loci associated with ageing.

bioRxiv · Mar 1, 2023Cell Biology

Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects

N. A. Robertson, E. Latorre-Crespo, M. Terrada-Terradas, A. C. Purcell, B. J. Livesey, J. A. Marsh, L. Murphy, A. Fawkes, L. MacGillvray, M. Copland, R. E. Marioni, S. E. Harris, S. R. Cox, I. J. Deary, L. J. Schumacher, , T. Chandra

This study quantifies gene-specific fitness effects of CHIP drivers over 12 years using longitudinal sequencing data and a new DIF filtering method, showing gene-specific differences can inform personalized clinical management.

bioRxiv · May 27, 2021Cell Biology