PARP inhibition in Ewing sarcoma: impact of germline DNA damage repair defects and activation of immunoregulatory pathways
L. M. Maurer, R. E. Venier, E. Mukherjee, C. M. Julian, J. D. Daley, N. G. Bailey, M. F. Jacobs, C. Kumar-Sinha, H. Raphel, K. Weiss, K. A. Janeway, R. Mody, P. C. Lucas, L. M. McAllister-Lucas, K. M. Bailey
This study shows that Ewing sarcoma cells with germline BARD1 mutations are sensitive to PARP inhibitors and that PARP inhibition increases PD-L1 expression, suggesting potential for combination immunotherapy.
bioRxiv · Sep 18, 2020 · PreprintCancer Biology