ImmunologybioRxivPreprint
In contrast to TH2-biased approaches, TH1 COVID-19 vaccines protect Syrian hamsters from severe disease in the absence of dexamethasone-treatable vaccine-associated enhanced respiratory pathology
A. Ebenig, S. Muraleedharan, J. Kazmierski…·M. D. Mühlebach
This study compares TH1 and TH2-biased vaccines in Syrian hamsters, showing that TH1 vaccines prevent severe disease without inducing VAERD, while TH2 vaccines cause VAERD through eosinophil recruitment and TH2 cytokine upregulation.
DOI 10.1101/2021.12.28.474359