J. Kazmierski

Single-cell-resolved interspecies comparison identifies a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19

The paper compares single-cell RNA-seq data from hamster and human COVID-19 samples to identify a shared inflammatory axis and a neutrophil-endothelial program associated with severe disease.

HIV-1 infection causes depletion of monocytic cells through a non-canonical cell death pathway

This study shows HIV-1 infection causes monocytic cell death via a non-canonical pathway independent of nucleic acid sensing or IFN signaling, requiring viral gene products and occurring after integration.

A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants

This study compares immune responses and efficacy of different SARS-CoV-2 vaccines in hamsters, finding that a live-attenuated vaccine provides superior protection against variants.

Non-productive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immunity responses

The paper shows that non-productive exposure of PBMCs to SARS-CoV-2 triggers JAK/STAT-dependent innate immune responses in monocytes, similar to those seen in mild COVID-19.

In contrast to TH2-biased approaches, TH1 COVID-19 vaccines protect Syrian hamsters from severe disease in the absence of dexamethasone-treatable vaccine-associated enhanced respiratory pathology

This study compares TH1 and TH2-biased vaccines in Syrian hamsters, showing that TH1 vaccines prevent severe disease without inducing VAERD, while TH2 vaccines cause VAERD through eosinophil recruitment and TH2 cytokine upregulation.

Post-entry, spike-dependent replication advantage of B.1.1.7 and B.1.617.2 over B.1 SARS-CoV-2 in an ACE2-deficient human lung cell line

The paper shows that B.1.1.7 and B.1.617.2 SARS-CoV-2 variants have a replication advantage over B.1 in ACE2-deficient lung cells, suggesting reliance on alternative cellular factors.

A base-line cellular antiviral state is maintained by cGAS and its most frequent naturally occurring variant rs610913

This study shows that the cGAS variant rs610913 maintains a baseline antiviral state, slightly altering susceptibility to viral infections without gross phenotypic differences.

Longitudinal omics in Syrian hamsters integrated with human data unravel complexity of moderate immune responses to SARS-CoV-2

The paper integrates longitudinal omics data from Syrian hamsters with human data to understand immune responses to SARS-CoV-2, identifying key cellular and molecular mechanisms.