Cell BiologybioRxiv
Changes in extracellular matrix cause RPE cells to make basal deposits and activate the alternative complement pathway.
R. Fernandez-Godino, K. M. Bujakowska, E. A. Pierce
This study shows that abnormal extracellular matrix from RPE cells triggers basal deposit formation and alternative complement pathway activation in AMD.
DOI 10.1093/hmg/ddx392