R. H. Mak

Targeting interleukin-1 for reversing fat browning and muscle wasting in infantile nephropathic cystinosis

This paper shows that anakinra, an IL-1 receptor antagonist, reduces fat browning and muscle wasting in Ctns-/- mice, suggesting it could treat cachexia in infantile nephropathic cystinosis.

The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia

This study shows that blocking IL-1 receptor reduces adipose browning and muscle wasting in CKD-associated cachexia in mice.