Author

R. Iacob

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Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

C. Lu· 1 shared J. Li· 1 shared J. R. Engen· 1 shared K. Bonazza· 1 shared N. Hudson· 1 shared T. A. Springer· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperBiophysics

C. Lu

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1 paper

Recent·Most cited

Von Willebrand factor A1 domain affinity for GPIbα and stability are differentially regulated by its O-glycosylated N-linker and C-linker

R. Iacob, K. Bonazza, N. Hudson, J. Li, C. Lu, J. R. Engen, T. A. Springer

This study investigates how O-glycosylated N- and C-linkers regulate the affinity and stability of the A1 domain of von Willebrand factor for GPIbα, revealing differential effects on binding and structural dynamics.

bioRxiv · Jan 13, 2022Biophysics