Shear Stress Initiates Endothelial-to-Mesenchymal Transition in Endocardial Endothelial Cells
K. N. Brown, H. K. T. Phan, T. Mustafa, E. Jui, F. N. Ahmad, R. K. Birla, J. P. Connell, P. Sucosky, S. G. Keswani, K. J. Grande-Allen
This study investigates how shear stress induces fibrosis in endocardial endothelial cells, showing it triggers EndMT signaling and gene expression changes that are more pronounced than Snail1 inhibition.
bioRxiv · Dec 5, 2022Bioengineering