Protein-specific signal peptides for mammalian vector engineering
P. O'Neill, R. K. Mistry, A. J. Brown, D. C. James
This paper develops a toolkit of signal peptides for mammalian cell expression, validated by increasing protein titers by 1.8x using machine learning and in silico/in vitro testing.
bioRxiv · Mar 14, 2023Bioengineering