A. J. Brown

Widespread Regulatory Turnover Across Human Segmental Duplications

This study investigates regulatory turnover in human segmental duplications using T2T genome assembly and ChIP-seq data, finding that regulatory elements are rarely conserved but gene expression and spatial proximity are preserved.

Chromatin state dynamics during the Plasmodium falciparum intraerythrocytic development cycle

This study examines chromatin state dynamics and TF binding in Plasmodium falciparum during its intraerythrocytic development cycle, revealing stable and dynamic chromatin states linked to gene regulation.

GPR35 inhibits TRPA1-mediated colonic afferent hypersensitivity through suppression of Substance P release

This paper identifies GPR35 as a target for non-opioid analgesics by showing it inhibits TRPA1-mediated colonic hypersensitivity through suppression of Substance P release.

Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice

The paper infects diverse mouse strains with a hepacivirus and shows host genetic variation influences viral clearance, chronicity, and liver fibrosis outcomes.

Protein-specific signal peptides for mammalian vector engineering

This paper develops a toolkit of signal peptides for mammalian cell expression, validated by increasing protein titers by 1.8x using machine learning and in silico/in vitro testing.

Human gut bifidobacteria inhibit the growth of the opportunistic fungal pathogen Candida albicans

This study shows that gut bifidobacteria inhibit Candida albicans growth through acid production, suggesting their potential as probiotic targets.

Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice.

This paper evaluates the therapeutic efficacy of GS-621763, an oral prodrug of remdesivir, against SARS-CoV-2 in mice, showing reduced viral load and improved lung function.

Modeling site-specific nucleotide biases affecting Himar1 transposon insertion frequencies in TnSeq datasets

This paper identifies site-specific nucleotide biases affecting Himar1 transposon insertion frequencies in TnSeq datasets and introduces a new method to improve the identification of conditionally essential genes.

A mouse-adapted SARS-CoV-2 model for the evaluation of COVID-19 medical countermeasures

This paper develops a mouse-adapted SARS-CoV-2 model to evaluate medical countermeasures, showing age-related disease severity and the efficacy of IFN lambda-1a.

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.

This study shows remdesivir effectively inhibits SARS-CoV-2 in human cells and mice, reducing viral load and improving lung function.

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

This study demonstrates that the antiviral NHC/EIDD-2801 inhibits SARS-CoV-2 and multiple coronaviruses, showing therapeutic efficacy and oral bioavailability in mice.

Dose and duration of IFNγ pre-licensing interact with donor characteristics to influence the expression and function of IDO in MSCs

This study examines how IFNγ dose and duration during MSC pre-licensing interact with donor characteristics to affect IDO expression and function.

Parp3 promotes long-range end-joining in murine cells

This study shows Parp3 promotes chromosomal rearrangements in murine cells, contrasting with Parp1's suppressive role in DNA double-strand break processing.