Early selection of the amino acid alphabet was adaptively shaped by biophysical constraints of foldability
M. Makarov, A. C. S. Rocha, R. Krystufek, I. Cherepashuk, V. Dzmitruk, T. Charnavets, A. M. Faustino, M. Lebl, K. Fujishima, S. D. Fried, K. Hlouchova
This study investigates why the modern amino acid alphabet evolved to include 20 canonical amino acids by showing that foldability constraints shaped the selection of early amino acids.
bioRxiv · Jun 14, 2022Biophysics