Author

M. Makarov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Assay:protein structure· 1

Frequent Co-Authors

K. Hlouchova· 3 shared K. Fujishima· 2 shared V. G. Giacobelli· 2 shared A. Brezinova· 1 shared A. C. S. Rocha· 1 shared A. C. Sanchez Rocha· 1 shared A. K. Dunker· 1 shared A. M. Faustino· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiophysics

K. Hlouchova

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The interplay between peptides and RNA is critical for protoribosome compartmentalization and stability

S. Codispoti, T. Yamaguchi, M. Makarov, V. G. Giacobelli, M. Masek, M. H. Kolar, A. C. Sanchez Rocha, K. Fujishima, G. Zanchetta, K. Hlouchova

This paper investigates the role of ribosomal peptides in protoribosome compartmentalization and stability, showing that RNA-protein interactions protect RNA from degradation and influence structural flexibility.

bioRxiv · Jan 29, 2024Biophysics

Early selection of the amino acid alphabet was adaptively shaped by biophysical constraints of foldability

M. Makarov, A. C. S. Rocha, R. Krystufek, I. Cherepashuk, V. Dzmitruk, T. Charnavets, A. M. Faustino, M. Lebl, K. Fujishima, S. D. Fried, K. Hlouchova

This study investigates why the modern amino acid alphabet evolved to include 20 canonical amino acids by showing that foldability constraints shaped the selection of early amino acids.

bioRxiv · Jun 14, 2022Biophysics

NAD precursors cycle between host tissues and the gut microbiome

K. Chellappa, M. R. McReynolds, W. Lu, X. Zeng, M. Makarov, F. Hayat, S. Mukherjee, Y. R. Bhat, S. R. Lingala, R. T. Shima, H. C. Descamps, T. Cox, L. Ji, C. Jankowski, Q. Chu, , J. A. Baur

The paper shows NAD precursors cycle between host tissues and the gut microbiome to maintain NAD homeostasis.

bioRxiv · Nov 15, 2021Physiology

Enzyme catalysis prior to aromatic residues: reverse engineering of a dephosphoCoA kinase

M. Makarov, J. Meng, V. Tretyachenko, P. Srb, A. Brezinova, V. G. Giacobelli, L. Bednarova, J. Vondrasek, A. K. Dunker, K. Hlouchova

This study shows that enzyme catalysis can occur without aromatic amino acids by testing variants of dephosphoCoA kinase with reduced amino acid alphabets.

bioRxiv · Nov 11, 2020Biochemistry