Fibrosis resolution in the mouse liver: role of Mmp12 and potential role of Calpain 1/2
T. Sato, K. Z. Head, J. Li, C. E. Dolin, D. Wilkey, N. Skirtich, D. D. McCreary, S. Liu, J. I. Beier, R. M. McEnaney, M. L. Merchant, G. E. Arteel
This study examines the role of MMP12 and Calpain 1/2 in liver fibrosis resolution using a mouse model, finding that MMP12 inhibition delays resolution and Calpains may contribute to protein degradation.
bioRxiv · Feb 15, 2022Pathology