Author

M. L. Merchant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 4 Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. W. Wilkey· 2 shared G. E. Arteel· 2 shared J. I. Beier· 2 shared J. Li· 2 shared T. Sato· 2 shared A. Duarte-Rojo· 1 shared A. Humar· 1 shared A. Parkanyi· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersPathology

D. W. Wilkey

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The plasma degradome reflects later development of NASH fibrosis after liver transplant

J. Li, T. Sato, M. Hernandez-Tejero, J. I. Beier, K. Sayed, P. V. Benos, D. W. Wilkey, A. Humar, M. L. Merchant, A. Duarte-Rojo, G. E. Arteel

The paper identifies a plasma degradome profile predictive of post-liver transplant NASH fibrosis using peptide analysis in human and mouse samples.

bioRxiv · Jan 30, 2023 · PreprintPathology

Fibrosis resolution in the mouse liver: role of Mmp12 and potential role of Calpain 1/2

T. Sato, K. Z. Head, J. Li, C. E. Dolin, D. Wilkey, N. Skirtich, D. D. McCreary, S. Liu, J. I. Beier, R. M. McEnaney, M. L. Merchant, G. E. Arteel

This study examines the role of MMP12 and Calpain 1/2 in liver fibrosis resolution using a mouse model, finding that MMP12 inhibition delays resolution and Calpains may contribute to protein degradation.

bioRxiv · Feb 15, 2022Pathology

Antitumor activity of a lectibody targeting cancer-associated high-mannose glycans

Y. J. Oh, M. Dent, A. R. Freels, Q. Zhou, C. B. Lebrilla, M. L. Merchant, N. Matoba

This study demonstrates that AvFc, a lectibody targeting high-mannose glycans, inhibits cancer cell migration and tumor growth in mice by blocking EGFR and IGF1R activation.

bioRxiv · Apr 28, 2021Cancer Biology

Disordered peptides impair neutrophil bacterial clearance and enhance tissue damage in septic patients

C. I. Timar, F. Kolonics, V. Berzsenyi, E. Tamaska, A. Parkanyi, M. L. Merchant, D. W. Wilkey, Z. Ivanyi, K. R. McLeish, E. Ligeti

The paper shows that disordered peptides in septic patients' plasma impair neutrophil function and increase tissue damage by altering ROS production and bacterial clearance.

bioRxiv · Jul 31, 2020 · PreprintImmunology