R. McPherson

Constitutive Photomorphogenesis Protein 1 homolog (COP1) sustains nuclear factor-4 alpha function in human hepatocyte models

This study shows COP1 maintains HNF4A function in primary hepatocytes and HepG2 cells but not HuH-7 cells, challenging previous links between COP1 and hepatic tumorigenesis.

"Wissenschaft fürs Wohnzimmer" - two years of interactive, scientific livestreams weekly on YouTube

The paper reports on two years of weekly YouTube livestreams discussing climate change and biodiversity, showing growth in views and subscriptions through diverse presenters and interactive content.

Regulation of TRIB1 abundance in hepatoma models

This study investigates TRIB1 regulation in hepatoma models, finding that proteasome inhibition increases TRIB1 levels but does not stabilize it, suggesting proteasome-independent degradation and transcriptional regulation as key mechanisms.

A common polymorphism that protects from cardiovascular disease increases fibronectin processing and secretion

The paper identifies a common polymorphism in the FN1 gene that reduces cardiovascular disease risk by altering fibronectin secretion and glycosylation.

The antimicrobial peptide cathelicidin is critical for the development of Th17 responses in severe inflammatory disease

This study shows cathelicidin promotes Th17 responses and severe EAE by enhancing T cell differentiation and plasticity, and its absence protects mice from disease.