Disruption of the MreB elongasome is overcome by mutations in the TCA cycle
B. Barton, A. Grinnell, R. Morgenstein
The paper shows that deleting malate dehydrogenase from the TCA cycle increases bacterial tolerance to the MreB-targeting antibiotic A22 and the cell wall-targeting antibiotic mecillinam.
bioRxiv · Jun 18, 2020 · PreprintMicrobiology