Aging skeletal muscle proteomics finds changes in spliceosome, immune factors, proteostasis and mitochondria
C. Ubaida-Mohien, A. Lyashkov, M. Gonzalez-Freire, R. Tharakan, M. Shardell, R. Ruin Moaddel, R. D. Semba, C. W. Chia, M. Gorospe, R. Sen, L. Ferrucci
This study identifies age-related changes in skeletal muscle proteomics, showing deficits in energy metabolism, increased inflammation, proteostasis, and alternative splicing.
bioRxiv · Jul 11, 2019 · PreprintPhysiology