L. Ferrucci

Psychosocial experiences are associated with human brain mitochondrial biology

This study links psychosocial experiences to mitochondrial biology in the human brain, finding positive experiences correlate with higher OxPhos machinery abundance and negative experiences with lower abundance.

Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest

This study investigates BAFF's role in senescence by showing its cell-type-specific effects on SASP and growth arrest.

Genetic, Clinical Underpinnings of Brain Change Along Two Neuroanatomical Dimensions of Clinically-defined Alzheimer's Disease

This study identifies two brain atrophy dimensions in Alzheimer's disease using Surreal-GAN and links them to genetic and clinical factors, revealing distinct pathological mechanisms.

Accelerating the clock: Interconnected speedup of energetic and molecular dynamics during aging in cultured human cells

This study shows that human cells age faster when they consume energy more rapidly, linking metabolic rate to molecular aging markers across the lifespan.

Single-cell analysis of skeletal muscle macrophages reveals age- associated functional subpopulations

This study identifies age-associated functional subpopulations of skeletal muscle macrophages using single-cell transcriptomics in mice.

Unbiased Proteomics, Histochemistry, and Mitochondrial DNA Copy Number Reveal Better Mitochondrial Health in Muscle of High Functioning Octogenarians

This study compares proteomics, histochemistry, and mitochondrial DNA copy number in muscle samples of high-functioning octogenarians and controls to identify markers of mitochondrial health.

HiIDDD: A high-throughput imaging pipeline for the quantitative detection of DNA damage in primary human immune cells

HiIDDD provides a high-throughput imaging method to detect DNA damage in primary human immune cells, showing consistent results across cell types and donors.

Mitochondrial Respiratory Chain Protein Co-Regulation in the Human Brain

The paper characterizes co-regulation patterns of mitochondrial respiratory chain proteins in the human brain across three cohorts, finding differential co-regulation between nuclear and mitochondrial DNA-encoded subunits and reduced complex I abundance in Alzheimer's disease.

A Proteomic Atlas of Senescence-Associated Secretomes for Aging Biomarker Development

The paper develops a proteomic atlas of senescence-associated secretomes to identify aging biomarkers, finding that GDF15, STC1, and SERPINs correlate with age in human plasma.

Aging skeletal muscle proteomics finds changes in spliceosome, immune factors, proteostasis and mitochondria

This study identifies age-related changes in skeletal muscle proteomics, showing deficits in energy metabolism, increased inflammation, proteostasis, and alternative splicing.

Automated methods for 3D Segmentation of Focused Ion Beam-Scanning Electron Microscopic Images

The paper introduces automated methods for 3D segmentation of FIB-SEM images, significantly improving analysis speed compared to manual approaches.