Natural mutations of human XDH promote the nitrite (NO2-)-reductase capacity of xanthine oxidoreductase: a novel mechanism to promote redox health?
G. MASSIMO, R. S. Khambata, T. Chapman, K. Birchall, A. Shabbir, N. Dyson, K. Rathod, C. Borghi, A. Ahluwalia
This study examines how natural mutations in human XDH affect XOR activity, revealing varied impacts on UA, ROS, and NO production, and suggests potential therapeutic strategies for cardiovascular disease.
bioRxiv · Mar 24, 2023 · PreprintBiochemistry