Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2
R. Tsutsumi, J. Harizanova, R. Stockert, K. Schröder, P. I. H. Bastiaens, B. G. Neel
The paper visualizes SHP2 oxidation in cells using a combined PLA and chemical labeling assay, revealing PDGF-induced spatial and temporal regulation of SHP2 oxidation near endosomes.
bioRxiv · Jun 29, 2017Cell Biology