Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies.
A. V. R. Lake, C. E. L. Smith, S. Natarajan, B. Basu, S. K. Best, T. Stevenson, R. Trowbridge, S. N. Grellscheid, J. Bond, R. Foster, C. A. Johnson
The paper identifies ROCK2 as a therapeutic target for ciliopathies through drug and siRNA screens, showing ROCK2 inhibitors could treat cystic kidney disease.
bioRxiv · Nov 26, 2020Cell Biology