TIGIT drives the immunosuppressive environment by downregulation of metalloproteinases MMP2 and MMP14 in perihilar cholangiocarcinoma.
L. Heij, K. Reichel, W. de Koning, J. Bednarsch, X. Tan, J. Campello Deierl, M. Clahsen-van Groningen, T. Al-Masri, R. van Dam, J. Garcia Vallejo, F. Ulmer, S. Lang, T. Luedde, F. Rocha, E. Dahl, , U. Neumann
This study examines TIGIT's role in perihilar cholangiocarcinoma by showing its association with immunosuppressive markers and MMP2/MMP14 downregulation.
bioRxiv · Aug 14, 2023 · PreprintCancer Biology