Huntingtin turnover: Modulation of huntingtin degradation by cAMP-dependent protein kinase A (PKA) phosphorylation of C-HEAT domain Ser2550
Y. Lee, H. Kim, D. Barker, R. Vijayvargia, R. S. Atwal, H. Specht, H. Keshishian, S. A. Carr, R. Lee, S. Kwak, K.-g. Hyun, J. Loupe, M. E. MacDonald, J.-J. Song, I. Seong
The paper identifies phospho-sites in huntingtin, showing PKA phosphorylation of Ser2550 in the C-HEAT domain accelerates its degradation.
bioRxiv · May 4, 2022 · PreprintBiochemistry