Author

J.-J. Song

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 3 Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 6 Research Focus:chromatin & epigenetic regulation· 5 Research Focus:protein folding & dynamics· 5 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Approach:statistical model· 3 Approach:biophysical modeling· 2

Frequent Co-Authors

C. Kang· 3 shared H. Hebert· 3 shared S. Hohng· 3 shared E. Lee· 2 shared E. Yoon· 2 shared H. Kim· 2 shared S. J. Kim· 2 shared T. Jung· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiophysics

C. Kang

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Author profile →

10 papers

Recent·Most cited

Huntingtin bundles and changes the local proteome of actin filaments in neurons

R. Carpentier, M. Capizzi, H. Kim, J. Novion-Ducassou, E. Denarier, B. Blot, Y. Coute, I. Arnal, J.-J. Song, S. Humbert

This study shows that Huntingtin (HTT) binds to F-actin, bundles actin filaments, and modulates the association of Drebrin1 with actin, affecting axonal growth and cytoskeletal organization in neurons.

bioRxiv · Aug 29, 2023Cell Biology

AMLs harboring DNMT3A-destabilizing variants show increased intratumor DNA methylation heterogeneity at bivalent chromatin domains

D. Lee, B. Koo, S.-H. Kim, J. Byun, J. Hong, D.-Y. Shin, C.-H. Sun, J.-J. Song, J. Kim, S. Jaiswal, S.-s. Yoon, S. Kim, Y. Koh

This study shows that DNMT3A-destabilizing mutations in AML increase DNA methylation heterogeneity at bivalent chromatin domains, affecting leukemic stem cell-niche interactions and drug response.

bioRxiv · Feb 13, 2023 · PreprintCancer Biology

Caf1 regulates Ash1 histone methyltransferase activity via sensing unmodified histone H3.

E. Yoon, J.-J. Song

The paper investigates how Caf1 regulates Ash1's histone methyltransferase activity by sensing unmodified histone H3K4, revealing a regulatory crosstalk between H3K4 and H3K36 methylation.

bioRxiv · Jan 24, 2023 · PreprintBiochemistry

Huntingtin turnover: Modulation of huntingtin degradation by cAMP-dependent protein kinase A (PKA) phosphorylation of C-HEAT domain Ser2550

Y. Lee, H. Kim, D. Barker, R. Vijayvargia, R. S. Atwal, H. Specht, H. Keshishian, S. A. Carr, R. Lee, S. Kwak, K.-g. Hyun, J. Loupe, M. E. MacDonald, J.-J. Song, I. Seong

The paper identifies phospho-sites in huntingtin, showing PKA phosphorylation of Ser2550 in the C-HEAT domain accelerates its degradation.

bioRxiv · May 4, 2022 · PreprintBiochemistry

Cryo-EM structure of human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand binding specificity

Y. Heo, E. Yoon, Y.-E. Jeon, J.-H. Yun, N. Ishimoto, H. Woo, S.-Y. Park, J.-J. Song, W. Lee

The paper reports the cryo-EM structure of human SSTR2 bound to somatostatin, revealing ligand binding specificity and interactions with Gi proteins.

bioRxiv · Jan 5, 2022Biophysics

Dendrimer-like supramolecular assembly of proteins with a tunable size and valency through stepwise iterative growth

J. H. Bae, H.-S. Kim, G. Kim, J.-J. Song, H.-S. Kim

This paper introduces a programmable method to create tunable, multi-valent protein assemblies called prodrimers, showing enhanced binding affinity and cytotoxicity.

bioRxiv · Jun 23, 2021Bioengineering

CHD7 interacts with the nucleosome acidic patch for its efficient activity via its N-terminal region

E. Lee, C. Kang, P. Purhonen, H. Hebert, K. Bouazoune, S. Hohng, J.-J. Song

This study identifies the N-terminal region of CHD7 as critical for its ATPase activity and nucleosome remodeling through interactions with the nucleosome acidic patch.

bioRxiv · Nov 19, 2020 · PreprintBiochemistry

Yeast Chd1p remodels nucleosomes with unique DNA unwrapping and translocation dynamics

J. Kirk, J. Y. Lee, Y. Lee, C. Kang, S. Shin, E. Lee, J.-J. Song, S. Hohng

This study uses single-molecule techniques to show that yeast CHD1 remodels nucleosomes through unique DNA unwrapping and translocation dynamics involving ATP binding and hydrolysis.

bioRxiv · Feb 6, 2020 · PreprintBiophysics

Structural basis of recognition and destabilization of histone H2B ubiquitinated nucleosome by DOT1L histone H3 Lys79 methyltransferase

S. Jang, C. Kang, H.-S. Yang, T. Jung, H. Hebert, K. Y. Jung, S. J. Kim, S. Hohng, J.-J. Song

The paper presents cryo-EM structures of DOT1L with nucleosomes and shows H2B ubiquitination enhances DOT1L's non-catalytic nucleosome destabilization function.

bioRxiv · Dec 31, 2018Biophysics

Integrative structure investigation on the architecture of human Importin4_histone H3/H4_Asf1a complex and its histone H3 tail binding

J. Yoon, S. J. Kim, S. An, A. Leitner, T. Jung, R. Aebersold, H. Hebert, U.-S. Cho, J.-J. Song

This study investigates the structure of the Importin4_histone H3/H4_Asf1a complex and identifies key interactions between Importin4 and the histone H3 tail.

bioRxiv · Sep 6, 2017Biochemistry