Cancer BiologybioRxiv
Isoform-specific Disruption of the TP73 Gene Reveals a Critical Role for TAp73gamma in Tumorigenesis via Leptin
X. Kong, W. Yan, W. Sun…·X. Chen
This study shows that the p73{gamma}-Leptin pathway promotes tumorigenesis and alters lipid metabolism by demonstrating that E11 deletion increases p73{gamma} and Leptin, leading to oncogenic effects in mice and human cancers.
DOI 10.7554/elife.82115