Paw placement during walking is altered by analgesic doses of opioids and post-surgical injury in mice
V. E. Brings, M. A. Payne, R. W. Gereau
This study shows that analgesic opioid doses alter hind paw placement in mice, causing a tiptoe-like gait, which affects the reliability of paw-directed assays for measuring opioid analgesia.
bioRxiv · Dec 15, 2021 · PreprintPharmacology & Toxicology