Venous activation of MEK/ERK drives development of arteriovenous malformation and blood 2 flow anomalies with loss of Rasa1
Jasper Greysson-Wong, Rachael Rode, Jae‐Ryeon Ryu, Kristina D. Rinker, Sarah J. Childs
The paper shows that loss of Rasa1 in zebrafish leads to AVMs through venous MEK/ERK overactivation, altered blood flow, and reduced klf2a expression.
bioRxiv · Jul 21, 2021 · PreprintDevelopmental Biology