Sarah J. Childs

This study shows that bradycardia reduces mural cell numbers in developing brain vasculature by impairing mechanosensory and Jag2-Notch signaling, and that restoring Jag2b rescues this defect.

The paper identifies a functional SNV in Versican associated with Cerebral Small Vessel Disease using MPRA and validates its effect on transcriptional activity.

The paper shows brain pericytes come from multiple sources, including fibroblasts, and their numbers adjust with vessel development.

This study uses zebrafish foxf2 mutants to model Cerebral Small Vessel Disease, showing progressive pericyte deficiencies and vascular abnormalities across the lifespan.

This study identifies nkx3.1-expressing precursors in zebrafish that differentiate into brain pericytes and shows their regulation by cxcl12b-Cxcr4 signaling.

Vessel Metrics is a software tool that automates vascular structure analysis in confocal images, improving consistency and efficiency across research groups.

This study shows Hnrnpul1 loss of function in zebrafish causes skeletal and limb defects and links it to human congenital limb malformations.

This study identifies Sema3fb's role in modulating VEGF signaling to regulate endothelial sprouting during vascular development.

The paper shows that loss of Rasa1 in zebrafish leads to AVMs through venous MEK/ERK overactivation, altered blood flow, and reduced klf2a expression.

The paper investigates the development of vascular myogenic responses in zebrafish, showing that pericytes and vascular smooth muscle cells regulate vascular tone at different developmental stages.

The paper traces the morphogenesis and transcriptome of early vascular smooth muscle cells in zebrafish using foxc1b as a marker.

The paper shows miR26 regulates BMP signaling in endothelial cells, indirectly promoting differentiated smooth muscle phenotype and vascular stability.