Altered chromatin accessibility and nucleosome positioning landscape upon HDAC and LSD1 inhibition in cancer cell
Sagnik Sen, Pierre Olivier Esteve, Devesh Tarasia, Rachel Danneberg, Ashmita Dey, Ujjwal Maulik, Sanghamitra Bandyopadhyay, Sriharsa Pradhan
The paper investigates how HDAC and LSD1 inhibition alters chromatin accessibility and nucleosome positioning in cancer cells, revealing a JunB-mediated mechanism that highlights therapeutic vulnerabilities.
bioRxiv · Apr 11, 2026 · PreprintGenetics