Sagnik Sen

The paper shows that oxidized TRX1 and DPP8/9 stabilize the MIA40-AIFM1 complex during intrinsic apoptosis, promoting NLRP1 restraint and preventing pyroptosis.

The paper investigates how HDAC and LSD1 inhibition alters chromatin accessibility and nucleosome positioning in cancer cells, revealing a JunB-mediated mechanism that highlights therapeutic vulnerabilities.

The paper shows that PIWI protein-dependent DNA N6-adenine methylation protects genomic sequences from deletion in Oxytricha during nuclear differentiation.

The paper shows RNA Pol I inhibition disrupts nucleolar structure, alters NPM1 localization, and changes chromatin landscape through histone modifications and DNA methylation.

The paper uses NEED-seq to show lamin B1 and B2 associate with distinct heterochromatin states and are linked to neuronal development.

The paper shows that promoter-adjacent DNA hypermethylation in TBX15 reduces gene expression in myoblasts and skeletal muscle without silencing it, suggesting a regulatory role in preventing overexpression.

This study shows that PARP1 poly ADP-ribosylates SET8, impairing its function and leading to altered H4K20 methylation domains and chromatin states.

The paper introduces a multiplex network framework to identify immunological markers for Mild Moderate Alzheimer's Disease by analyzing autoantibodies and their functional relationships.

The paper proposes a framework to identify diagnostic and therapeutic autoantibodies for neurodegenerative diseases and multiple sclerosis using statistical and structural analysis.

This paper identifies structural facets of POU2F1 critical for stable binding and prevents monomeric aggregation, linking its dynamicity to functional multiplicity in pan-cancer analysis.