Author

Rachel Darley

University of Southampton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Andy van HatereniD· 1 shared Jonathan W. EssexiD· 1 shared Malcolm J. W. SimiD· 1 shared Steven TurneriD· 1 shared Tim J ElliottiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperImmunology

Andy van HaterenORCID

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1 paper

Recent·Most cited

Atom-level mechanism of tapasin-independent peptide editing by Major Histocompatibility Complex class I molecules

Steven Turner, Rachel Darley, Jonathan W. Essex, Malcolm J. W. Sim, Andy van Hateren, Tim J Elliott

The paper investigates tapasin-independent peptide editing by MHC-I molecules using molecular dynamics simulations, revealing an 'active displacement' mechanism that explains peptide selection and immunogenic epitope presentation.

bioRxiv · Jun 20, 2025 · PreprintImmunology