Decoding Gene Responsiveness to Synthetic Chromatin Reader-Actuators with Multi-Modal Epigenomic Profiling
Seong Hu Kim, Isioma Enwerem-Lackland, Natecia L. Williams, Rachel Fisher, Christopher L. Plaisier, Karmella Ann Haynes
The paper uses synthetic reader-actuators to study how chromatin context influences gene inducibility in MCF7 cells, finding that SRA responsiveness depends on a chromatin signature beyond H3K27me3.
npj Systems Biology and Applications · Aug 3, 2026Peer-reviewedSynthetic Biology