Author

Isioma Enwerem-Lackland

Emory UniversityORCID 0000-0002-3014-3307Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Karmella Ann HaynesiD· 2 shared Aaron C. GoldstrohmiD· 1 shared Ai Lin· 1 shared Christopher L. PlaisieriD· 1 shared Chung-Te ChangiD· 1 shared Eric J. WagneriD· 1 shared Eric WargaiD· 1 shared Eugene ValkoviD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersSynthetic Biology

Karmella Ann HaynesORCID

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Author profile →

3 papers

Recent·Most cited

Decoding Gene Responsiveness to Synthetic Chromatin Reader-Actuators with Multi-Modal Epigenomic Profiling

Seong Hu Kim, Isioma Enwerem-Lackland, Natecia L. Williams, Rachel Fisher, Christopher L. Plaisier, Karmella Ann Haynes

The paper uses synthetic reader-actuators to study how chromatin context influences gene inducibility in MCF7 cells, finding that SRA responsiveness depends on a chromatin signature beyond H3K27me3.

npj Systems Biology and Applications · Aug 3, 2026Peer-reviewedSynthetic Biology

Targeted regulation of plasmid DNA expression in eukaryotic cells with a methylated-DNA-binding activator

Isioma Enwerem-Lackland, Eric Warga, Margaret Dugoni, Jacob J. Elmer, Karmella Ann Haynes

The paper introduces a system to regulate plasmid DNA expression in eukaryotic cells by targeting methylated DNA using a fusion protein that binds to GATC motifs.

bioRxiv · Nov 1, 2021 · PreprintSynthetic Biology

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome

Isioma Enwerem-Lackland, Nathan D. Elrod, Chung-Te Chang, Ai Lin, Ping Ji, Jennifer A. Bohn, Yevgen Levdansky, Eric J. Wagner, Eugene Valkov, Aaron C. Goldstrohm

This study identifies how PUM1 and PUM2 regulate gene expression by interacting with the CCR4-NOT complex and DCP2 to repress mRNA decay.

RNA · Jan 4, 2021Peer-reviewedMolecular Biology