Christopher L. Plaisier

This study demonstrates that monocyte-mimetic nanoparticles delivering Verteporfin reduce plaque progression and promote fibrotic remodeling in atherosclerosis by targeting inflamed endothelium and modulating macrophage populations.

The paper uses synthetic reader-actuators to study how chromatin context influences gene inducibility in MCF7 cells, finding that SRA responsiveness depends on a chromatin signature beyond H3K27me3.

The paper establishes and characterizes IDH-mutant astrocytoma cell lines, revealing NOTCH-regulated plasticity between astrocyte-like and oligodendrocyte-like states.

The paper compares differential expression and co-expression network analysis for microglia transcriptomics, finding co-expression analysis better identifies functional ontologies.

This study examines sex-dependent changes in circulating steroid hormones and cortical gene expression following traumatic brain injury in mice, revealing sex-specific alterations in hormone levels and gene expression related to immune and tissue responses.

This study shows that physiologic glucose and oxygen levels influence human cortical development by altering metabolic states and cell fate decisions in organoids.

This study characterizes quiescent subpopulations and proliferative compartments in glioblastoma, finding that quiescent cells continuously cycle and lack stable dormant states.

The paper introduces ccAFv2, a high-resolution cell cycle classifier for scRNA-seq data, which outperforms existing methods and classifies six cell cycle states and a quiescent-like G0 state.

OncoMerge integrates protein-affecting mutations, gene fusions, and copy number alterations to create a unified somatic mutation profile, improving downstream cancer analysis.

The paper builds genome-scale transcriptional regulatory networks for mouse and human striatum, identifying SMAD3 as a key regulator in Huntington’s disease.