Smooth muscle cell estrogen receptor alpha promotes arterial stiffness in the absence of estradiol
Casey G. Turner, Jacqueline Matz, Jade Breton, Karla de Oliveira, Rachel Kenney, Jennifer Vorn, Michelle J Zhao, Jaime Ibarrola, Qing Richard Lu, Gregory Martin, Zhe Sun, Iris Zamir Jaffe, M. R. Hill, Jennifer J. DuPont
This study shows that smooth muscle cell estrogen receptor alpha promotes arterial stiffness in both female and male mice when estradiol levels are low, through sex-specific mechanisms.
bioRxiv · Mar 5, 2026 · PreprintPhysiology