Cell enlargement drives aging-associated proteome remodeling and shortens replicative lifespan
Michael Charles Lanz, Manuel Hotz, Rachel Kroll-Ling, Eileen Wang, Jabob Kim, Joshua Eric Elias, Daniel E. Gottschling, Jan Marcel Skotheim
This study shows that cell enlargement drives proteome remodeling and shortens replicative lifespan in yeast, independent of known aging factors.
bioRxiv · Feb 16, 2026 · PreprintCell Biology