Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney disease
Swayam Prakash Srivastava, Han Zhou, Rachel Shenoi, Myshal Morris, Begoña Lainez, Yuta Takagaki, Barani Kumar Rajendran, Ocean Setia, Binod Kumar Aryal, Keizo Kanasaki, Daisuke Koya, Ken Inoki, Alan Dardik, Carlos F Fernandez-Hernando, Gerald I. Shulman, Julie E. Goodwin
This study shows that endothelial ANGPTL4 depletion prevents diabetic kidney disease by improving metabolic function and reducing inflammation.
bioRxiv · May 8, 2025 · PreprintMolecular Biology