Author

Swayam Prakash Srivastava

University of MichiganORCID 0000-0002-7162-3091Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Ken InokiiD· 3 shared Aaron Thurman· 2 shared Abhiram Kunamneni· 2 shared Arya JoshiiD· 2 shared Daisuke KoyaiD· 2 shared Keizo KanasakiiD· 2 shared Olivia Kopasz-Gemmen· 2 shared Om Khuperkar· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Ken InokiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

AMPK is dispensable for physiological podocyte and glomerular functions but prevents glomerular fibrosis in experimental diabetes

Swayam Prakash Srivastava, Olivia Kopasz-Gemmen, Abhiram Kunamneni, Aaron Thurman, Shota Yoshida, E. Elif Ozkan, Vinamra Swaroop, Rahul Nanwani, Ajan Arora, Arya Joshi, Om Khuperkar, Mariam Hamed, Mihir Suresh Bharadwaj, Niloy Islam, Adesh Urval, , Ken Inoki

This study shows that AMPK is not essential for normal podocyte function but is critical for preventing glomerular fibrosis in diabetes.

Cell Death Discovery · Mar 28, 2026Peer-reviewedCell Biology

HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis

Takayuki Ikeda, Sungki Hong, Shota Yoshida, Swayam Prakash Srivastava, Abhiram Kunamneni, Yao Yao, Om Khuperkar, Venkatesha Basrur, Henry Kuang, Maureen T. Kachman, Abraham Raskind, Heidi Baum, Arya Joshi, Vinamra Swaroop, Aaron Thurman, , Ken Inoki

This study shows HUWE1 enhances mTORC1 activity by promoting Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis via CAD activation.

Cell Reports · Oct 1, 2025Peer-reviewedBiochemistry

Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney disease

Swayam Prakash Srivastava, Han Zhou, Rachel Shenoi, Myshal Morris, Begoña Lainez, Yuta Takagaki, Barani Kumar Rajendran, Ocean Setia, Binod Kumar Aryal, Keizo Kanasaki, Daisuke Koya, Ken Inoki, Alan Dardik, Carlos F Fernandez-Hernando, Gerald I. Shulman, Julie E. Goodwin

This study shows that endothelial ANGPTL4 depletion prevents diabetic kidney disease by improving metabolic function and reducing inflammation.

bioRxiv · May 8, 2025 · PreprintMolecular Biology