Rapamycin enhances VEGFA and VSMC contractile protein expression in MSCs via mTORC1 inhibition
Pedro Bartkevitch Rodrigues, Sai Sanikommu, Omar S. Elwardany, Tiffany Alyssa Eatz, Rachele Angiolini, Helena Hernandez-Cuervo, Naser Hamad, Jennifer Suon, Maxon V. Knott, Joshua M. Hare, John W. Thompson, Robert M. Starke
This study shows rapamycin increases VSMC protein markers and VEGFA in MSCs via mTORC1 inhibition, suggesting potential therapeutic use in cerebral aneurysm treatment.
bioRxiv · Aug 5, 2025 · PreprintNeuroscience