Joshua M. Hare

This study uses cardiac organoids derived from patient iPSCs to show that LMNA haploinsufficiency causes early fibrotic signaling, which can be targeted by antifibrotic drugs.

This study identifies the HIF-1 pathway as mediating the cardioprotective effects of GHRH-agonists in a murine model of cardiometabolic HFpEF.

This paper shows that KSHV uses eIF5B to mimic hypoxia and support viral replication and oncogenesis by altering translation initiation.

This study identifies ER stress and nitroso-redox imbalance as key drivers of NEPC progression and shows that NO supplementation reduces tumor burden and metastasis in mice.

The paper develops a novel vessel tortuosity scale to predict cerebral aneurysm formation and rupture in a mouse model.

This study shows rapamycin increases VSMC protein markers and VEGFA in MSCs via mTORC1 inhibition, suggesting potential therapeutic use in cerebral aneurysm treatment.

This study investigates the use of rapamycin-coated coils and stents as drug delivery platforms for cerebral aneurysm treatment, showing sustained drug release and mTOR inhibition.

This paper identifies an O2-independent HIF-1 mechanism regulated by GH/IGF1/SST signaling that controls cardiomyocyte growth through metabolic shifts.

The paper investigates the postnatal fate of developmental gene regulatory networks in the heart, identifying persistent contributions from neural crest-derived cardiomyocytes.

This study identifies βPix as a regulator of LDLR stability by sequestering IDOL, preventing LDLR degradation, and reducing LDL-C uptake in Alport Syndrome models.