Structural mechanism of Gasdermin E-mediated mtDNA release from apoptotic mitochondria
Lisa Hohorst, Raed Shalaby, Nadine Gehle, Zakarya Benayad, Vincent Z. Braun, Lars Richter, Sina Azami, KC Farrell, Asma Majoul, Shashank Dadsena, Eleonora Germana Margheritis, Christina Kunz, Simone Prinz, Laurens Wachsmuth, Sabine Wilhelm, , Ana J. García Sáez
This study identifies GSDME-N as a mediator of mitochondrial inner membrane permeabilization and mtDNA release during apoptosis, revealing its structural mechanism and impact on inflammatory responses.
bioRxiv · Sep 30, 2026 · PreprintMolecular Biology