Condensate formation of the human RNA-binding protein SMAUG1 is controlled by its intrinsically disordered regions and interactions with 14-3-3 proteins
Olivia Carey, John Fehilly, Eoghan Thomas O’Leary, Stephen O’Shea, Klaudia Juda, Rahel Fitzel, Pooja Selvaraj, Katja Burk, Andrew J. Lindsay, Paul William Young, Rita Pancsa, Bálint Mészáros, Kellie A. Dean
This paper shows that SMAUG1 forms condensates via its disordered region and that 14-3-3 proteins dissolve these condensates through phospho-regulated interactions.
Journal of Molecular Biology · Jul 2, 2025Peer-reviewedMolecular Biology