Pharmacological Depletion of Retinal Mononuclear Phagocytes is Neuroprotective in a Mouse Model of Mitochondrial Optic Neuropathy
Avital Lily Okrent Smolar, Rahul Viswanath, Howard M. Bomze, Hao Ying, Sandra S. Stinnett, Sidney M. Gospe
This study shows that pharmacological depletion of retinal mononuclear phagocytes with pexidartinib, combined with hypoxia, completely protects retinal ganglion cells in a mouse model of mitochondrial optic neuropathy.
Investigative Ophthalmology & Visual Science · Feb 2, 2026Peer-reviewedNeuroscience